In A Large Bowl, Combine Ketchup, Brown Sugar, Red Wine Vinegar, Dijon-Style Mustard, Worcestershire Sauce, And Liquid Smoke. Stir In Salt, Pepper, And Garlic Powder. Place Chuck Roast In A Slow Cooker. Pour Ketchup Mixture Over Chuck Roast. Cover, And Cook On Low For 8 To 10 Hours. Remove Chuck Roast From Slow Cooker, Shred With A Fork, And Return To The Slow Cooker. Stir Meat To Evenly Coat With Sauce. Continue Cooking Approximately 1 Hour.