Preheat An Outdoor Grill For Medium-High Heat; Lightly Oil The Grate. Combine The Ground Beef, Beer, Worcestershire Sauce, Whiskey, Garlic Powder, Onion Powder, Salt, And Pepper In A Bowl; Mix Until Evenly Combined. Shape The Mixture Into 6 Patties. Cook On The Preheated Grill Until The Burgers Are Cooked To Your Desired Degree Of Doneness, 5 To 8 Minutes Per Side For Well Done. An Instant-Read Thermometer Inserted Into The Center Should Read 160 Degrees F (70 Degrees C).